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Assessment of current practice of prescription of SGLT2 inhibitors in a tertiary care hospital- an observational study
To assess the current prescribing practice of SGLT2 inhibitors in patients to understand and update the treatment plans for future patients.
- To conduct an observational study to evaluate adherence to guidelines on prescription of SGLT2 inhibitors following Diabetes Mellitus.
- To assess the indications and reasons for starting SGLT2 inhibitors and to evaluate the adverse drug reactions.
MATERIALS AND METHOD
In this study, a sample size of 50 patients prescription details are checked and the current prescription practice of clinicians (indications, regimen and the duration) and is compared with existing guidelines. Another aspect of the study is to look at the clinical effectiveness (glycemic status and cardiac status) and the side effects encountered by the patients. Trends in new prescriptions and subsequent 3month adjusted changes in glycemic response (reduction in HbA1c), weight, blood pressure and rates of hypoglycaemia, creatinine levels and treatment discontinuation were examined.
In the assessment of prescribing patterns of 50 patients, a 69% of the prescriptions were following the guidelines and 22% were prescribed out of the guidelines and less than 9% the drug was discontinued, and accordingly, the justifications given for prescribing the drug was recorded and analysed. The drugs were found to cause a decrease in glycemic levels, increase in Creatinine levels and also showed urinary tract infections.
In the assessment of current prescribing patterns of SGLT2inhibitors, a major part of the prescriptions were following guidelines, at the same time, a good number of prescriptions were prescribed outside the guidelines. Therefore, appropriate guidelines for the prescription of SGLT2I should be developed which can promote uniform and appropriate prescription of the drugs that come under SGLT2I.
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