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An Analysis of Histamine 2 Receptor Antagonists and a Proposal for Lafutidine

Matthew Christopher Buchfellner


On April 1st, 2020, the Food and Drug Administration (FDA) made national headlines when it published a press release on the removal of Zantac, a popularly prescribed histamine-2 receptor antagonist in the United States. Due to this removal, and the subsequent fallout, it has become necessary to search for alternative H2RA's. Lafutidine, a marketed drug in Japan and India, has proven safety and efficacy as an H2RA option for the treatment of gastric ulcers and other gastrointestinal diseases. Larger scale clinical trials into Lafutidine use in the United States could solve problems that have arisen since the discontinuation of Zantac.


Healthcare; Pharmacy; Global Health; FDA; Lafutidine; H2RA; PPI


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