Assess the appropriateness of antimicrobial agents in hospital with the importance of empirical therapy and assisted re-evaluation by clinical pharmacist

Abstract

ABSTRACT:

Objective:

To optimize restricted antibiotic use in treatment and prophylaxis of infections among hospitalized patients in order to improve clinical outcomes by adopting the rational use of antibiotics in the critical care units at the tertiary care hospital.

Methods:

During routine ward rounds with consultants, the clinical pharmacist was made to follow all the prescriptions with restricted antibiotics. The rationality was checked for the appropriate use and the case was followed until patient’s discharge or death.

Results:

We evaluated the appropriateness of restricted antibiomicrobials use in the tertiary care hospital. Three antimicrobials were selected Piperacilin Tazobactum (171 prescriptions), Meropenam (120 Prescriptions) and Colistin (61 Prescriptions). Out of 290 prescriptions (total 764 antibiotics) screened, 290 prescriptions was prescribed with 455 (59.55%) restricted antibiotics. Piptaz (60%) was the most commonly used restricted antibiotics followed by Meropenam (41%) and followed by Colistin (21%). The commonly implicated organism were Klebsialla (68 prescriptions) followed by E-coli (32 prescriptions) and coagulase negative (27 prescriptions). No growth was observed in 143 prescriptions and total of 85 interventions was done.

Conclusion:

The use of restricted antibiotics are alarmingly has increased in current clinical practice. An intense monitoring by clinical pharmacist can certainly have an impact on judicious prescribing of the antibiotics.