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Misapplication and overexploitation of antibiotics fuel the antimicrobial resistance in India
Abstract
The discovery of penicillin by Sir Alexander Fleming in 1928 was the stepping stone to the modern era of antibiotics. Since then, antibiotics have saved millions of lives and transformed the practice of treating infections. The emerging antimicrobial resistance (AMR) warrant newer and stronger antibiotics. Bacteria appear to have followed the Darwin's theory of the survival of the fittest and outsmarted humans by evolving into highly resistant ‘superbugs’, posing a severe threat to mankind. AMR is triggered by prolonged overuse as well as the misuse of antibiotics. Unnecessary prescriptions and lack of awareness among patients further worsens the current scenario – with recent research suggesting that reducing consumption may not result in a drastic change in AMR. Drug resistant infections continue to rise steadily in low and middle income countries like India, owing to poor sanitation, irrational antibiotic use and low public health spending. This article summarizes the causes of AMR and overuse of reserve antibiotics in India despite its large burden of infectious diseases.
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References
Webb HE, Angulo FJ, Granier SA, Scott HM, Loneragan GH. Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin. F1000Research. 2017;6.
Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and therapeutics. 2015 Apr;40(4):277.
Ventola CL. The antibiotic resistance crisis: part 2: management strategies and new agents. Pharmacy and Therapeutics. 2015 May;40(5):344.
Tan SY, Tatsumura Y. Alexander Fleming (1881–1955): discoverer of penicillin. Singapore medical journal. 2015 Jul;56(7):366.
Spellberg B, Gilbert DN. The future of antibiotics and resistance: a tribute to a career of leadership by John Bartlett. Clinical infectious diseases. 2014 Sep 15;59(suppl_2):S71-5.
Zaman SB, Hussain MA, Nye R, Mehta V, Mamun KT, Hossain N. A review on antibiotic resistance: alarm bells are ringing. Cureus. 2017 ;9(6).
O’neill JI. AMR: tackling a crisis for the health and wealth of nations. Review on AMR. 2014 Dec 11;1(1):1-6.6)
Laxminarayan R, Heymann DL. Challenges of drug resistance in the developing world. Bmj. 2012 Apr 3;344:e1567.
Kunin CM, Tupasi T, Craig WA. Use of antibiotics: a brief exposition of the problem and some tentative solutions. Annals of Internal Medicine. 1973 Oct 1;79(4):555-60.
Ganguly NK, Arora NK, Chandy SJ, Fairoze MN, Gill JP, Gupta U, Hossain S, Joglekar S, Joshi PC, Kakkar M, Kotwani A. Global antibiotic resistance partnership (GARP): India Working Group. Rationalizing antibiotic use to limit antibiotic resistance in India. Indian J Med Res. 2011;134(3):281-94.7)
Laxminarayan R, Chaudhury RR. Antibiotic resistance in India: drivers and opportunities for action. PLoS medicine. 2016 Mar 2;13(3):e1001974.
Kakkar M, Walia K, Vong S, Chatterjee P, Sharma A. Antibiotic resistance and its containment in India. bmj. 2017 Sep 5;358:j2687.
Weiner LM, Webb AK, Limbago B, Dudeck MA, Patel J, Kallen AJ, Edwards JR, Sievert DM. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014. infection control & hospital epidemiology. 2016 Nov;37(11):1288-301.
Read AF, Woods RJ. Antibiotic resistance management. Evolution, medicine, and public health. 2014;2014(1):147.
Piddock LJ. The crisis of no new antibiotics—what is the way forward?. The Lancet infectious diseases. 2012 Mar 1;12(3):249-53.
Kaur A, Bhagat R, Kaur N, Shafiq N, Gautam V, Malhotra S, Suri V, Bhalla A. A study of antibiotic prescription pattern in patients referred to tertiary care center in Northern India. Therapeutic advances in infectious disease. 2018 Jul;5(4):63-8.16)
Ahmad A, Khan MU, Balkrishnan R. Fixed-dose combination antibiotics in India: global perspectives. The Lancet Global Health. 2016 Aug 1;4(8):e521.
Larsson DJ. Pollution from drug manufacturing: review and perspectives. Philosophical Transactions of the Royal Society B: Biological Sciences. 2014 Nov 19;369(1656):20130571.
Mathew G, Unnikrishnan MK. The emerging environmental burden from pharmaceuticals. Economic and Political Weekly. 2012 May 5:31-4.
Davies M, Walsh TR. A colistin crisis in India. The Lancet Infectious Diseases. 2018 Mar 1;18(3):256-7.
Scientific Advisory Group on Antimicrobials of the Committee for Medicinal Products for Veterinary Use. Reflection paper on the use of third and fourth generation cephalosporins in food producing animals in the European Union: development of resistance and impact on human and animal health. Journal of veterinary pharmacology and therapeutics. 2009 Dec;32(6):515-33.
Witte W. Medical consequences of antibiotic use in agriculture.
Koyama Y. A new antibiotic'colistin'produced by spore-forming soil bacteria. J. Antibiot.. 1950;3:457-8.
Falagas ME, Kasiakou SK, Saravolatz LD. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clinical infectious diseases. 2005 May 1;40(9):1333-41.
Skov RL, Monnet DL. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Eurosurveillance. 2016 Mar 3;21(9):30155.
Nhung NT, Chansiripornchai N, Carrique-Mas JJ. AMR in bacterial poultry pathogens: a review. Frontiers in veterinary science. 2017 Aug 10;4:126.
McGettigan P, Roderick P, Kadam A, Pollock AM. Access, Watch, and Reserve antibiotics in India: challenges for WHO stewardship. The Lancet Global health. 2017 Nov 1;5(11):e1075-6.
Farooqui HH, Selvaraj S, Mehta A, Heymann DL. Community level antibiotic utilization in India and its comparison vis-à-vis European countries: Evidence from pharmaceutical sales data. PloS one. 2018 Oct 17;13(10):e0204805.
Laxminarayan R, Heymann DL. Challenges of drug resistance in the developing world. Bmj. 2012 Apr 3;344:e1567.
Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, Greko C. Antibiotic resistance—the need for global solutions. The Lancet infectious diseases. 2013 Dec 1;13(12):1057-98.
Kollef MH, Micek ST. Rational use of antibiotics in the ICU: balancing stewardship and clinical outcomes. JAMA. 2014 Oct 8;312(14):1403-4.
Sivagnanam G, Mohanasundaram J, Thirumalaikolundusubramanian P, Raaj AA, Namasivayam K, Rajaram S. A survey on current attitude of practicing physicians upon usage of antimicrobial agents in southern part of India. Medscape General Medicine. 2004;6(2).
Walsh C, Wencewicz T. Antibiotics: challenges, mechanisms, opportunities. American Society for Microbiology (ASM); 2016.